RUNX2 (C-term) Rabbit Polyclonal Antibody

CAT#: AP23378PU-N

RUNX2 (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Immunohistochemistry with CBFA1 Polyclonal Antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1 μg/ml.
  Immunohistochemistry on paraffin sections 1-2 μg/ml.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a sequence at the C-terminal of human CBFA1
• Specificity: This antibody detects RUNX2 (C-term). No cross reactivity with other proteins.
• Formulation: 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3
  State: Aff - Purified
  State: Lyophilized Ig fraction
• Reconstitution Method: 0.2ml of distilled water will yield a concentration of 500μg/ml.
• Purification: Immunogen affinity purified
• Storage: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens runt related transcription factor 2 (RUNX2), transcript variant 2
• Database Link:
  Entrez Gene 12393 MouseEntrez Gene 367218 RatEntrez Gene 860 Human
• Background: Core binding factor A1 (CBFA1/RUNX2) is a runt-like transcription factor essential for osteoblast differentiation. This protein is a member of the RUNX family of transcription factors and has a Runt DNA-binding domain. It is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. D'Souza et al.(1999) indicate a non-redundant role for Cbfa1 in tooth development that may be distinct from that in bone formation. In odontogenesis, Cbfa1 is not involved in the early signaling networks regulating tooth initiation and early morphogenesis but regulates key epithelial-mesenchymal interactions that control advancing morphogenesis and histodifferentiation of the epithelial enamel organ.
• Synonyms: Runt-related transcription factor 2, Acute myeloid leukemia 3 protein, AML3, AML-3, CBFA1, OSF2, OSF-2, PEBP2A, PEA2-alpha A, PEBP2-alpha A

Reference Data

• Protein Families: Druggable Genome, Transcription Factors