Glucocorticoid Receptor (NR3C1) (C-term) Rabbit Polyclonal Antibody

CAT#: AP23379PU-N

Glucocorticoid Receptor (NR3C1) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Immunohistochemistry with Glucocoticoid Receptor polyclonal antibody (Human mammary cancer).

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: Use at 1 μg/ml with the appropriate system to detect GR in cells and tissues.
  Immunohistochemistry on Frozen Sections.
  Immunohistochemistry on Paraffin Sections: Use at 0.5-1 μg/ml to detect GR in formalin fixed and paraffin embedded tissues.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a sequence at the C-terminal of Human GR
• Specificity: This antibody detects Glucocorticoid receptor (C-term). No cross reactivity with other proteins.
• Formulation: 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal and 0.05mg Sodium Azide
  State: Aff - Purified
  State: Lyophilized purified IgG fraction
• Reconstitution Method: Restore with 0.2 ml of distilled water to yield a concentration of 0.5 mg/ml.
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Store the antibody after reconstitution at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens nuclear receptor subfamily 3 group C member 1 (NR3C1), transcript variant 1
• Database Link:
  Entrez Gene 14815 MouseEntrez Gene 24413 RatEntrez Gene 2908 Human
• Background: Glucocorticoid receptor(GR) maps to the distal long arm of chromosome 5. The human glucocorticoid receptor (hGR) gene contains a total of 10 exons and has a minimum size of 80 kilobases. The identification of complementary DNAs encoding the human glucocorticoid receptor (hGR) predicts two protein forms (alpha and beta; 777 and 742 amino acids long, respectively) which differ at their carboxy termini and both forms of the receptor are related, with respect to their domain structure, to the v-erb-A oncogene product of avian erythroblastosis virus (AEV), which suggests that steroid receptor genes and the c-erb-A proto-oncogene are derived from a common primordial regulatory gene. Transcriptional regulation by the glucocorticoid receptor (GR) is mediated by hormone binding, receptor dimerization, and coactivator recruitment.
• Synonyms: NR3C1, GR, GRL

Reference Data

• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
• Protein Pathways: Neuroactive ligand-receptor interaction