NF-kB p65 (RELA) (N-term) Rabbit Polyclonal Antibody

CAT#: AP23407PU-N

NF-kB p65 (RELA) (N-term) rabbit polyclonal antibody, Aff - Purified


USD 405.00

2 Weeks*

Size
    • 100 ug

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Other products for "RELA"

Specifications

Product Data
Applications WB
Recommended Dilution Western blot: 1 μg/ml.
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen A synthetic peptide mapping at the N-terminal of human NFκBP65
Specificity This antibody detects RELA / NF-kB p65. No cross reactivity with other proteins.
Formulation 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3
State: Aff - Purified
State: Lyophilized Ig fraction
Reconstitution Method 0.2ml of distilled water will yield a concentration of 500μg/ml.
Purification Immunogen affinity purified
Storage Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), transcript variant 1
Background The p65 (RELA) heterodimer is the most abundant form of NFKB. This gene is located on 11q13, which consists of 10 exons and spans about 8.1 kb of DNA1. In rat sciatic nerves, the expression of the activated p65 subunit of NFKB was high in the nuclei of premyelinating Schwann cells and then progressively declined until it was nearly absent in adults2. The transcriptional activity of NF-kappa-B is stimulated upon phosphorylation of its p65 subunit on serine-276 by protein kinase A (PKA). The transcriptional coactivator CBP /p300 associates with NF-kappa-B p65 through 2 sites, an N-terminal domain that interacts with the C-terminal region of unphosphorylated p65, and a second domain that only interacts with p65 phosphorylated on serine-2763.
Synonyms NF kappa B p65, NFkB p65, Transcription factor p65, Rel A, NFKB3
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Acute myeloid leukemia, Adipocytokine signaling pathway, Apoptosis, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Cytosolic DNA-sensing pathway, Epithelial cell signaling in Helicobacter pylori infection, MAPK signaling pathway, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Pancreatic cancer, Pathways in cancer, Prostate cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer, T cell receptor signaling pathway, Toll-like receptor signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.