TNFRSF1B (N-term) Rabbit Polyclonal Antibody

CAT#: AP23408PU-N

TNFRSF1B (N-term) rabbit polyclonal antibody, Aff - Purified


USD 405.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Applications IHC, WB
Recommended Dilution Western blot: 2 μg/ml.
Immunohistochemistry on paraffin sections: 2 μg/ml.
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen A synthetic peptide corresponding to a sequence in the middle region of human TNFR2/TNFRSF1B.
Specificity This antibody detects CD120b / TNFR2 (N-term). No cross reactivity with other proteins.
Formulation 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3
State: Aff - Purified
State: Lyophilized Ig fraction
Reconstitution Method 0.2ml of distilled water will yield a concentration of 500μg/ml.
Purification Immunogen affinity purified
Storage Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens TNF receptor superfamily member 1B (TNFRSF1B)
Background Tumor necrosis factor receptor 2 (TNFR2) is one of receptors of TNF. TNF has proinflammatory and immunosuppressive properties that may segregate at the level of the 2 TNF receptors (TNFRs), TNFR1 and TNFR2. The genes for TNFR1, a 55-kDa protein, and TNFR2, a 70-kDa protein, have been mapped to human chromosomes 12 (12pter-cen) and 1 (1pter-p32), respectively. TNFR2 was induced on glomerular endothelial cells of nephritic kidneys, and TNFR2 expression on intrinsic cells, but not leukocytes, was essential for glomerulonephritis and glomerular complement deposition. TNFR1 promotes systemic immune responses and renal T cell death, while intrinsic cell TNFR2 plays a critical role in complement-dependent tissue injury. Therefore, therapeutic blockade specifically of TNFR2 may be a promising strategy in the treatment of immune-mediated glomerulonephritis.
Synonyms Tumor necrosis factor receptor 2, p80 TNF-alpha receptor, TNFRSF1B, TNFBR, TNF-R2
Reference Data
Protein Families Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways Adipocytokine signaling pathway, Amyotrophic lateral sclerosis (ALS), Cytokine-cytokine receptor interaction

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.