CCL28 Rabbit Polyclonal Antibody

CAT#: AP23432PU-S

CCL28 rabbit polyclonal antibody, Aff - Purified


USD 260.00

2 Weeks*

Size
    • 50 ug

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Specifications

Product Data
Applications ELISA, IF, WB
Recommended Dilution Sandwich ELISA: To detect Human MEC by Sandwich ELISA (using 100μl/well antibody solution) a concentration of 0.5-2.0 μg/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human MEC (Cat.-No AP23432BT-N or AP23432BT-S) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of recombinant Human MEC.
Western Blot: To detect Human MEC by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant Human MEC is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions. 
Immunofluorescence: This antibody (Lots 0211M242Rb and 0811M242Rb) stained CACO-2 cells. The primary antibody was incubated at 3.0 µg/ml overnight at 4°C followed by a fluorescent labeled secondary antibody. Information courtesy of the Cell Profiling group, SciLifeLab Stockholm.
Reactivities Human
Host Rabbit
Clonality Polyclonal
Immunogen Highly pure E.coli derived recombinant Human MEC (Cat.-No PA246)
Specificity Recognizes Human MEC. Other species not tested.
Formulation PBS, pH 7.2 without preservatives
State: Aff - Purified
State: Lyophilized (sterile filtered) purified Ig fraction
Reconstitution Method Centrifuge vial prior to opening. Restore in sterile water to a concentration of 0.1-1.0 mg/ml.
Purification Affinity Chromatography employing an immobilized Human MEC matrix.
Gene Name Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 1
Background CCL28, also known as chemokine (C-C motif) ligand 28 or mucosae-associated epithelial chemokine (MEC), belongs to the subfamily of small cytokine CC proteins. CCL28 is expressed by columnar epithelial cells in the gut, lung, breast and the salivary glands and drives the mucosal homing of T and B lymphocytes that express CCR10, and the migration of eosinophils expressing CCR3. This chemokine is constitutively expressed in the colon, but its levels can be increased by pro-inflammatory cytokines and certain bacterial products implying a role in effector cell recruitment to sites of epithelial injury.
Synonyms C-C motif chemokine 28, SCYA28
Reference Data
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Chemokine signaling pathway, Cytokine-cytokine receptor interaction

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.