Col17a1 Rabbit Polyclonal Antibody

CAT#: AP23435PU-N

Col17a1 rabbit polyclonal antibody, Purified

Product Images

Immunofluorescence staining of Collagen type XVII alpha 1 chain with Cat.No. AP23435PU-N (1:100) followed by an anti-rabbit FITC conjugated secondary antibody in cryosections of mouse skin.

Specifications

Product Data

• Applications: IF, IHC
• Recommended Dilution: Immunofluorescence.
  Immunohistochemistry on Cryosections.
• Reactivities: Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Mouse COL17A
• Specificity: Recognizes Mouse Collagen type XVII. Other species not tested.
• Formulation: PBS pH 7.4
  State: Purified
  State: Lyophilized purified IgG fraction from Serum
• Reconstitution Method: Restore in aqua bidest to initial volume
• Purification: Protein G Chromatography
• Gene Name: Mus musculus collagen, type XVII, alpha 1 (Col17a1), transcript variant 2
• Database Link:
  Entrez Gene 12821 Mouse
• Background: Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in the gene coding for collagen XVII are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD 1, is generated by proteolytic processing of the full length form. Two transcript variants, one resulting from alternative splicing in the 3' UTR, have been identified for this gene.
• Synonyms: COL17A1, BP180, BPAG2, Bullous pemphigoid antigen 2, LAD-1, LABD97