TNF Rabbit Polyclonal Antibody

CAT#: AP23442SU-N

TNF rabbit polyclonal antibody, Serum


USD 550.00

2 Weeks*

Size
    • 100 ul

Product Images

Specifications

Product Data
Applications IHC, R, WB
Recommended Dilution RIA.
Western Blot.
Immunohistochemistry.
Reactivities Bovine
Host Rabbit
Clonality Polyclonal
Immunogen Recombinant Bovine Tumor Necrosis Factor alpha (TNF alpha)
Specificity Recognizes Bovine TNF alpha.
No cross reaction with other Growth Factors.
Formulation State: Serum
State: Lyophilized Serum
Reconstitution Method Restore in aqua bidest to initial volume.
Background Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide stimulated macrophages, and causes tumor necrosis when injected into tumour bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS PAGE under non reducing conditions. TNF alpha is closely related to the 25 kDa protein Tumour Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.
Synonyms TNF, TNF-a, TNFA, TNFSF2, Cachectin
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.