LGR7 (RXFP1) (609-624) Rabbit Polyclonal Antibody

CAT#: AP23448SU-S

LGR7 (RXFP1) (609-624) rabbit polyclonal antibody, Serum

Product Images

Immunohistochemistry of RXFP1 staining in Paraffin Section of healthy Human breast tissue from lactating patient. The section was incubated with AP23448SU (1/5000) overnight and detected using Peroxidase anti Peroxidase (PAP)-Avidin-Biotin-Complex (ABC) combination method. DAB was used as the chromogen. The section was counter-stained with haemalaun. A: AP23448SU recognizes the stromal cells within the glands. B: Preimmune serum at the same dilution. Scale bar = 50 µm Ivell Re et al. (2003) Reprod Biol Endocrinol 1:114

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Western Blot.
  Immunocytochemistry: 1/4000 (Ref.1).
  Immunohistochemistry on Paraffin Sections: 1/5000 (Ref.1,2).
• Reactivities: Human, Monkey, Mouse, Porcine, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic Human Relaxin Receptor 1 (aa 609-624) KLH-conjugated
• Specificity: Recognizes Human Relaxin Receptor 1 (609-624).
  There was no cross reactivity obtained with Human Relaxin Receptor 2 (RXFP2, LGR8)
• Formulation: State: Serum
  State: Lyophilized Serum
• Reconstitution Method: Restore in aqua bidest to initial volume.
• Gene Name: Homo sapiens relaxin/insulin like family peptide receptor 1 (RXFP1), transcript variant 1
• Database Link:
  Entrez Gene 295144 RatEntrez Gene 381489 MouseEntrez Gene 701107 MonkeyEntrez Gene 59350 Human
• Background: LGR7 is a low density lipoprotein receptor of 757 amino acid belonging to the G-protein coupled receptor 1 family with rhodopsin-like receptor activity. It has seven transmembrane region, cysteine-rich motif, 10 LRR domains and 5 N-glycosylation sites in the N terminus. Research reports show that it has receptor for relaxins (RLN1 and RLN2) which stimulates adenylate cyclase activation, substrate adhesion, and chemo migratory capacity of mononuclear leukocytes. LGR7 is critical for mediating these biological responses by use of RNA interference lentiviral short hairpin constructs. It is widely expressed in 86% of 15 primary EC tissue samples including brain, kidney, testis and endometrium.
• Synonyms: LGR7

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction