LGR8 (RXFP2) (144-158) Rabbit Polyclonal Antibody

CAT#: AP23449SU-N

LGR8 (RXFP2) (144-158) rabbit polyclonal antibody, Serum

Product Images

Immunohistochemistry of RXFP2 staining in Paraffin Section of Human testis. The section was incubated with AP23449SU (1/4000) overnight and detected using ABC stainig Kit. DAB was used as the chromogen. The section was counter-stained with haemalaun. A: AP23449SU recognizes interstitial Leydig cells and germ cells (arrow heads). B: Preimmune serum at the same dilution. Scale bar = 50 µm Anand-Ivell R et al. (2006) Biol Reprod 74:945-953.

Specifications

Product Data

• Applications: IF, IHC
• Recommended Dilution: Immunocytochemistry (1/4000) (Ref.1).
  Immunohistochemistry (1/4000) (Ref.1).
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic Human Relaxin Receptor 2 (144-158)
• Specificity: Recognizes Human Relaxin Receptor 2 (144-158).
  There was no cross reactivity obtained with Human Relaxin Receptor 1 (RXFP1, LGR7)
• Formulation: State: Serum
  State: Lyophilized Serum
• Reconstitution Method: Restore in aqua bidest to initial volume
• Gene Name: Homo sapiens relaxin/insulin-like family peptide receptor 2 (RXFP2), transcript variant 1
• Database Link:
  Entrez Gene 122042 Human
• Background: Relaxins are endocrine and autocrine/paracrine hormones belonging to the insulin gene superfamily. In several mammalian species, relaxin is best known for its role during pregnancy and parturition, when it is produced by the corpora lutea of ovaries and other reproductive tissues. The secretion of relaxin into the blood stream just before parturition results in a marked softening and lengthening of the pubic symphysis and a softening of the cervix, which facilitates the birth process. Also, by inhibiting uterine contractions, relaxin may influence the timing of parturition. Two previously characterized orphan receptors designated relaxin receptor 1 (LGR7) and 2 (LGR8) bind relaxin in several tissues, including reproductive tissues, brain, and heart. Upon ligand binding, the relaxin receptors activate adenylate cyclases through Gs proteins. Expression of the relaxin receptors in tissues other than reproductive ones suggests that they have additional physiological functions, such as regulating blood pressure and controlling vascular volume in the heart.
• Synonyms: G-protein coupled receptor 106, GPR106, GREAT, LGR8

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction