SQSTM1 (C-term) Rabbit Polyclonal Antibody

CAT#: AP23491PU-N

SQSTM1 (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of SQSTM1 in Human spleen tissue lysate with SQSTM1 antibody at (A) 1 and (B) 2 ug/ml.

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  Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 1 - 2 µg/ml.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A 14 amino acid peptide from near the carboxy terminus of Human SQSTM1.
• Specificity: Recognizes SQSTM1 (C-term).
• Formulation: PBS containing 0.02% Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purfied IgG fraction
• Concentration: 1 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens sequestosome 1 (SQSTM1), transcript variant 2
• Database Link:
  Entrez Gene 18412 MouseEntrez Gene 113894 RatEntrez Gene 8878 Human
• Background: SQSTM1/p62 is an adapter protein which binds ubiquitin and regulates signaling cascades through ubiquitination. It may regulate the activation of NF-kappaB by TNF-alpha, nerve growth factor (NGF) and interleukin-1. SQSTM1/p62, a co-interacting protein of the atypical PKC isoforms, has a UBA domain at its C-terminal end, which binds non-covalently to polyubiquitin chain. SQSTM1's UBA domain is necessary for recruitment of polyubiquitin and aggresome formation. SQSTM1 may play a role in titin/TTN downstream signaling in muscle cells and may be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels. Mutations in the ubiquitin-associated (UBA) domain of SQSTM1 commonly cause Paget’s disease of bone since the UBA is necessary for aggregate sequestration and cell survival.
• Synonyms: Sequestosome-1, EBIAP, ORCA, OSIL, p60, p62

Reference Data

• Protein Families: Druggable Genome, Transcription Factors