Nephrin (NPHS1) (C-term) Rabbit Polyclonal Antibody

CAT#: AP23552PU-N

Nephrin (NPHS1) (C-term) rabbit polyclonal antibody

Product Images

Formalin-Fixed, Paraffin-Embedded Human Kidney stained with Nephrin antibody at 5 ug/ml after heat-induced antigen retrieval.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 5 µg/ml.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Epitope: C-Terminus
• Specificity: This antibiody recognizes Nephrin.
• Formulation: PBS containing 0.02% Sodium Azide as preservative
  State: Liquid purfied Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens NPHS1 nephrin (NPHS1)
• Database Link:
  Entrez Gene 4868 Human
• Background:

  Nephrin Antibody: Nephrin is strongly expressed in renal glomeruli and is a member of the immunoglobulin family of cell adhesion molecules. Mutations in the Nephrin gene result in congenital nephrotic syndrome, an autosomal-recessive disorder characterized by massive proteinuria in utero and nephrosis at birth. Renal glomeruli allow normal kidneys to filter plasma so that it is very pure. Nephrin is expressed in the podocyte slit-diaphragm of the renal glomeruli in a manner that suggests that Nephrin molecules homodimerize in an anti-parallel fashion similar to cadherin interactions in adherens junctions. Thus, Nephrin may constitute the entire extracellular structure of the slit-diaphragm.

• Synonyms: NPHS1, NPHN

Reference Data

• Protein Families: Druggable Genome, Transmembrane