Myeloperoxidase (MPO) Rabbit Polyclonal Antibody

CAT#: AP23566PU-N

Myeloperoxidase (MPO) rabbit polyclonal antibody

Product Images

Human Spleen, Neutrophils: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 1/50.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Purified human granulocytic MPO
• Specificity: This antibody reats to Myeloperoxidase (MPO).
• Formulation: 10mM PBS, pH 7.4 containing 0.2% BSA as stabilizer and 0.09% Sodium Azide as preservative
  State: Liquid purfied IgG fraction
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens myeloperoxidase (MPO)
• Database Link:
  Entrez Gene 17523 MouseEntrez Gene 303413 RatEntrez Gene 4353 Human
• Background: Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains (12 kD) and 2 heavy chains (60 kD). This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. It is released in a degranulation process in response to bursts of oxygen consumption, which also forms H2O2. MPO and H2O2 form a complex that oxidases a large variety of substances some of which have microbicidal effects. The gene for MPO is translocated in patients with acute promyelocytic leukemia and is mutated in hereditary MPO deficiency.
• Synonyms: MPO

Reference Data

• Protein Families: Druggable Genome