PARK7 (167-189) Rabbit Polyclonal Antibody

CAT#: AP23572PU-N

PARK7 (167-189) rabbit polyclonal antibody, Aff - Purified

Product Images

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1/500 - 1/1000.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from human PARK7 / DJ-1 (aa 167-189)
• Specificity: This antibody detects residues 167-189 (AIVEALNGKEVAAQVKAPLVLKD) of human PARK7 (DJ-1).
• Formulation: PBS containing 0.02% sodium azide as preservative
  State: Aff - Purified
  State: Liquid purfied Ig fraction
• Concentration: 1 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens Parkinsonism associated deglycase (PARK7), transcript variant 2
• Database Link:
  Entrez Gene 57320 MouseEntrez Gene 11315 Human
• Background: Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death.
• Synonyms: Oncogene DJ1, Parkinson disease protein 7

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Parkinson's disease