Microsomal Glutathione S transferase 1 (MGST1) (40-71) Rabbit Polyclonal Antibody

CAT#: AP23578PU-N

Microsomal Glutathione S transferase 1 (MGST1) (40-71) rabbit polyclonal antibody

Product Images

Western blot of anti-MGST1 antibody Ca.-No in K562 cell line lysates (35 ug/lane).

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  Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 1/1000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide selected from the Center region of human MGST1.
• Specificity: This antibody recognizes the internal region of Glutathione S-transferase (MGST1).
• Formulation: PBS containing 0.09% Sodium Azide as preservative
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Ammonium Sulfate Precipitation
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens microsomal glutathione S-transferase 1 (MGST1), transcript variant 2
• Database Link:
  Entrez Gene 4257 Human
• Background: The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress.
• Synonyms: Microsomal GST-1, GST12, MGST

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Drug metabolism - cytochrome P450, Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450