Arginase 1 (ARG1) (1-145) Rabbit Polyclonal Antibody

CAT#: AP23580PU-N

Arginase 1 (ARG1) (1-145) rabbit polyclonal antibody, Aff - Purified

Product Images

Western Blot analysis using ARG1 antibody at 1/1000 dilution. Sample (30 ug of whole cell lysate). Lane A: Molt-4. Lane B: Raji. 12% SDS PAGE.

• 

  Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 1/500 - 1/3000.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Recombinant protein fragment containing a sequence corresponding to a region within amino acids 1 and 145 of Human Arginase-1
• Specificity: This antibody recognizes Arginase I at aa 1-145.
• Formulation: 0.1 M Tris-glycine, pH 7, 10% Glycerol, 0.01% Thimerosal
  State: Aff - Purified
  State: Liquid purfied Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Store the antibody (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens arginase 1 (ARG1), transcript variant 2
• Database Link:
  Entrez Gene 11846 MouseEntrez Gene 29221 RatEntrez Gene 383 Human
• Background: Arginase-1 (ARG1) catalyzes the hydrolysis of L-arginine into ornithine and urea, a critical step for the urea cycle. Defects in ARG1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia. There are several isoforms of mammalian arginase. The type I isoform, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Hepatocellular carcinoma usually shows higher protein expression of ARG1 than normal liver cells.
• Synonyms: Type I arginase, Liver-type arginase, ARG1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Arginine and proline metabolism, Metabolic pathways