MAD2 (MAD2L1) (1-174) Rabbit Polyclonal Antibody

CAT#: AP23587PU-N

MAD2 (MAD2L1) (1-174) rabbit polyclonal antibody, Aff - Purified

Product Images

Sample (30 ug of whole cell lysate). A: 293T. 12% SDS PAGE. MAD2L1 antibody diluted at 1/1000.

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  Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1/500 - 1/3000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Recombinant protein fragment containing a sequence corresponding to a region within amino acids 1 and 174 of Human MAD2
• Specificity: This antibody reacts to MAD2 Mitotic Arrest Deficient-like 1 (MAD2L1) at aa 1-174.
• Formulation: 0.1 M Tris-glycine, pH 7.0 containing 20% Glycerol as stabilizer and 0.01% Thimerosal as preservative
  State: Aff - Purified
  State: Liquid purfied Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Store the antibody at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens MAD2 mitotic arrest deficient-like 1 (yeast) (MAD2L1)
• Database Link:
  Entrez Gene 56150 MouseEntrez Gene 297176 RatEntrez Gene 4085 Human
• Background: Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.
• Synonyms: Mitotic spindle assembly checkpoint protein MAD2A, MAD2

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Cell cycle, Oocyte meiosis, Progesterone-mediated oocyte maturation