TPM1 (92-283) Rabbit Polyclonal Antibody

CAT#: AP23588PU-N

TPM1 (92-283) rabbit polyclonal antibody, Aff - Purified

Product Images

Sample (30 ug of whole cell lysate). A: A431. 12% SDS PAGE. TPM1 antibody diluted at 1/1000.

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  Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Recombinant protein fragment containing a sequence corresponding to a region within amino acids 92 - 283 of Human Tropomyosin 1
• Specificity: This antibody reacts to Tropomyosin Alpha Chain, Skeletal Muscle (TPM1) at aa 92-283.
• Formulation: 0.1 M Tris-glycine, pH 7.0 containing 20% Glycerol as stabilizer and 0.01% Thimerosal as preservative
  State: Aff - Purified
  State: Liquid purfied IgG fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Store the antibody (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant Tpm1.5
• Database Link:
  Entrez Gene 22003 MouseEntrez Gene 24851 RatEntrez Gene 7168 Human
• Background: TPM1 / Tropomyosin is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments.
• Synonyms: Tropomyosin alpha-1 chain, Alpha-tropomyosin, TMSA, C15orf13

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)