TMS1 (PYCARD) (31-46) Rabbit Polyclonal Antibody

CAT#: AP23602PU-N

TMS1 (PYCARD) (31-46) rabbit polyclonal antibody

Product Images

Western blot analysis for TMS1 using antibody at 2 ug/ml against 10 ug/lane of A549 cell lysate.

• 

  Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1 - 2 µg/ml.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide - KLH conjugated, Synthetic peptide
• Specificity: A mixture of synthetic peptides corresponding to amino acid residues 31-46 and 94-110 of human TMS1.
• Formulation: PBS containing 0.02% sodium azide.
  State: Liquid purfied Ig fraction
• Concentration: 0.5 mg/ml
• Purification: Protein G Chromatography
• Gene Name: Homo sapiens PYD and CARD domain containing (PYCARD), transcript variant 1
• Database Link:
  Entrez Gene 29108 Human
• Background: Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, BCL10, Apaf-1, ARC, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified in human and mouse and designated ASC and TMS1. Ectopic expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells. Overexpression of ASC/TMS1 induced DNA fragmentation. ASC/TMS1 is expressed in a variety of human and mouse tissues.
• Synonyms: TMS1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Cytosolic DNA-sensing pathway, NOD-like receptor signaling pathway