TLR7 (465-483) Rabbit Polyclonal Antibody

CAT#: AP23603PU-N

TLR7 (465-483) rabbit polyclonal antibody

Product Images

Western blot analysis of TLR7 in Ramos cell lysate using antibody at 1/500.

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  Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1/500 - 1/1000.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: KLH-conjugated synthetic peptide corresponding to amino acids 465-483 of human TLR7.
• Specificity: This antibody reacts to Toll-like Receptor 7 (TLR7). It will cross-react with mouse TLR7.
• Formulation: PBS containing 0.05% sodium azide as preservative
  State: Liquid purfied Ig fraction
• Concentration: 0.5 mg/ml
• Purification: Protein G Chromatography
• Gene Name: Homo sapiens toll like receptor 7 (TLR7)
• Database Link:
  Entrez Gene 170743 MouseEntrez Gene 51284 Human
• Background: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. TLR7, like TLRs 3, 8, and 9, is localized in intracellular acidic compartments such as the phagolysosome and will recognize some single-stranded RNA viruses such as vesicular stomatitis virus (VSV) and influenza virus. Activation of TLR7 by VSV results in stimulation of the immune response including IFNa secretion, suggesting the importance of TLR7 in virus recognition.
• Synonyms: Toll-like receptor 7

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Toll-like receptor signaling pathway