TLR7 (900-950) Rabbit Polyclonal Antibody

CAT#: AP23604PU-N

TLR7 (900-950) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of human TLR7 in Ramos cell lysate in the 1) absence and 2) presence of immunizing peptide using antibody at 1 ug/ml.

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  Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Intracellular staining by FACS analysis of TLR7 in human PBMCs using at 2 ug/ml. Shaded histogram represents cells alone; green represents rabbit IgG isotype control, ; red represents anti-TLR7 antibody. Goat anti-rabbit PE, was used as secondary.

Specifications

Product Data

• Applications: FC, IHC, WB
• Recommended Dilution: Flow Cytometry.
  Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 0.5 - 2 µg/ml.
• Reactivities: Human, Monkey
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from a portion of amino acids 900-950 of Human TLR7
• Specificity: This antibody reacts to Toll-like Receptor 7 (TLR7) at aa 900-950.
• Formulation: PBS
  State: Purified
  State: Liquid purfied Ig fraction
  Stabilizer: 0.05% BSA
  Preservative: 0.05% Sodium Azide
• Concentration: 0.5 mg/ml
• Purification: Protein G Chromatography
• Gene Name: Homo sapiens toll like receptor 7 (TLR7)
• Database Link:
  Entrez Gene 170743 MouseEntrez Gene 317468 RatEntrez Gene 51284 Human
• Background: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. TLR7, like TLRs 3, 8, and 9, is localized in intracellular acidic compartments such as the phagolysosome and will recognize some single-stranded RNA viruses such as vesicular stomatitis virus (VSV) and influenza virus. Activation of TLR7 by VSV results in stimulation of the immune response including IFNa secretion, suggesting the importance of TLR7 in virus recognition.
• Synonyms: Toll-like receptor 7

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Toll-like receptor signaling pathway