PAK1 (245-490) Rabbit Polyclonal Antibody

CAT#: AP23621PU-N

PAK1 (245-490) rabbit polyclonal antibody, Aff - Purified

Product Images

Sample (30 ug of whole cell lysate). A: A431. 7.5% SDS PAGE. PAK1 antibody diluted at 1/1000

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  Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1/500 - 1/3000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Recombinant protein fragment containing a sequence corresponding to a region within amino acids 245 and 490 of Human PAK1
• Specificity: This antibody reacts to PAK1 at aa 245-490.
• Formulation: 0.1 M Tris-glycine, pH 7.0 containing 10% Glycerol and 0.01% Thimerosal
  State: Aff - Purified
  State: Liquid purfied Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Store the antibody (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1), transcript variant 1
• Database Link:
  Entrez Gene 18479 MouseEntrez Gene 29431 RatEntrez Gene 5058 Human
• Background: PAK1, a PAK (STE20) type protein kinase, is an effector for the small GTP binding proteins Cdc42 and Rac in the regulation of cell motility and morphology. The activated protein has been shown to act on a variety of targets, including actin-binding protein filamin A, myosin light chain kinase, histone H3 and the stress-activated protein kinase JNK1. The PAK1 gene has been mapped to chromosome 11q13, a region of amplification in a subset of estrogen receptor positive breast carcinomas prone to metastasis.
• Synonyms: PAK 1, PAK-1, Alpha-PAK, PAK alpha, p21-activated kinase 1, p65-PAK

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Stem cell - Pluripotency
• Protein Pathways: Axon guidance, Chemokine signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Regulation of actin cytoskeleton, Renal cell carcinoma, T cell receptor signaling pathway