Cytochrome P450 26B (CYP26B1) (160-396) Rabbit Polyclonal Antibody

CAT#: AP23681PU-N

Cytochrome P450 26B (CYP26B1) (160-396) rabbit polyclonal antibody, Aff - Purified

Product Images

Sample (30 ug of whole cell lysate). Lane A: Hep G2. 7.5% SDS PAGE. CYP26B1 antibody diluted at 1/1000.

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  Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1/500 - 1/3000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Recombinant protein fragment containing a sequence corresponding to a region within amino acids 160 and 396 of Human Cytochrome P450 26B
• Specificity: This antibody recognizes CYP26B1 at aa160-396.
• Formulation: 0.1M Tris-glycine, pH 7, 20% Glycerol and 0.01% Thimerosal
  State: Aff - Purified
  State: Liquid purified IgG fraction
• Concentration: 1 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens cytochrome P450 family 26 subfamily B member 1 (CYP26B1), transcript variant 1
• Database Link:
  Entrez Gene 232174 MouseEntrez Gene 312495 RatEntrez Gene 56603 Human
• Background: Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Esential for postnatal survival.
• Synonyms: CYP26A2, Cytochrome P450RAI2, Cytochrome P450 26B1, Cytochrome P450 26A2

Reference Data

• Protein Families: Druggable Genome, P450
• Protein Pathways: Retinol metabolism