Cytochrome P450 26B (CYP26B1) (418-430) Goat Polyclonal Antibody

CAT#: AP23825PU-N

Cytochrome P450 26B (CYP26B1) (418-430) goat polyclonal antibody, Aff - Purified

Product Images

Human Small Intestine, Submucosal Plexus: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: ELISA: 1/128000.
  Immunohistochemistry on Paraffin Sections: 3.75 µg/ml.
• Reactivities: Equine, Hamster, Human, Monkey, Mouse, Rabbit, Rat
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from an internal region of human CYP26B1
• Specificity: This antibody reacts to the internal region of CYP26B1.
• Formulation: Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilizer and 0.02% sodium azide as preservative
  State: Aff - Purified
  State: Liquid purfied Ig fraction
• Concentration: 0.5 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens cytochrome P450 family 26 subfamily B member 1 (CYP26B1), transcript variant 1
• Database Link:
  Entrez Gene 232174 MouseEntrez Gene 312495 RatEntrez Gene 56603 Human
• Background: Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Esential for postnatal survival.
• Synonyms: CYP26A2, Cytochrome P450RAI2, Cytochrome P450 26B1, Cytochrome P450 26A2

Reference Data

• Protein Families: Druggable Genome, P450
• Protein Pathways: Retinol metabolism