NRG1 (Isoform 10) (N-term) Rabbit Polyclonal Antibody
Other products for "NRG1"
Specifications
Product Data | |
Applications | ELISA, IHC, WB |
Recommended Dilution | ELISA: 1/10000. Immunohistochemistry on Paraffin Sections: 1/200. Western Blot: 1/500 - 1/1000. |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Synthetic peptide - KLH conjugated |
Specificity | This antibody detects endogenous levels of total NRG1 isoform-10 protein. |
Formulation | PBS (without Mg2+, Ca2+), pH 7.4 containing 150mM Sodium Chloride, 0.02% Sodium Azide and 50% Glycerol State: Purified State: Liquid purified IgG fraction |
Concentration | lot specific |
Purification | Immunoaffinity Chromatography |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens neuregulin 1 (NRG1), transcript variant HRG-beta1c |
Database Link | |
Background | Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells. |
Synonyms | NRG1, GGF, HGL, HRGA, NDF, SMDF, Heregulin, HRG, Breast cancer cell differentiation factor p45, Glial growth factor, Neu differentiation factor |
Reference Data | |
Protein Families | Druggable Genome, Secreted Protein, Transcription Factors, Transmembrane |
Protein Pathways | ErbB signaling pathway |
Documents
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