ZSCAN4 (C-term) Rabbit Polyclonal Antibody

CAT#: AP23939PU-N

ZSCAN4 (C-term) rabbit polyclonal antibody, Purified

Product Images

Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 1 - 2 µg/ml.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: 18 amino acid peptide near the carboxy terminus of Human ZSCAN4
• Specificity: This antibody reacts to the C-term of Zinc Finger And SCAN Domain Containing 4 (ZSCAN4).
• Formulation: PBS containing 0.02% Sodium Azide as preservative
  State: Purified
  State: Liquid purfied Ig fraction
• Concentration: 1 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens zinc finger and SCAN domain containing 4 (ZSCAN4)
• Database Link:
  Entrez Gene 201516 Human
• Background: Zytotic genome activation (ZGA) is the first and most critical transition event from the maternal genetic to the embryonic genetic program and the major burst of ZGA occurs only in the late 2-cell stage. ZSCAN4 encodes a SCAN domain and four zinc finger domains and is expressed in late 2-cell embryos and embryonic stem cells. Loss-of-function studies using siRNA shows delays in the progression from the 2-cell to the 4-cell stage and subsequent embryo development. ZSCAN4 plays an important role in the preimplantation development. Also, ZSCAN4 is involved in telomere maintenance and long term genomic stability in ES cells, suggesting that ZSCAN4 may be of critical importance in maintaining pluripotency in replicating stem cells.
• Synonyms: ZNF494, Zinc finger protein 494

Reference Data

• Protein Families: Transcription Factors