DR5 (TNFRSF10B) (380-398) Rabbit Polyclonal Antibody

CAT#: AP23951PU-N

DR5 (TNFRSF10B) (380-398) rabbit polyclonal antibody, Aff - Purified

Product Images

Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from Human TNFRSF10B / DR5, aa 380-398
• Specificity: This antibody reacts to Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) at aa 380-398.
• Formulation: PBS containing 0.02% Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purfied Ig fraction
• Concentration: 1 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens tumor necrosis factor receptor superfamily member 10b (TNFRSF10B), transcript variant 1
• Database Link:
  Entrez Gene 8795 Human
• Background: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB.
• Synonyms: TNFRSF10B, DR5, KILLER, TRICK2, ZTNFR9, Death receptor 5, TRAIL receptor 2, TRAIL-R2

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity, p53 signaling pathway