SH3KBP1 (2-14) Goat Polyclonal Antibody

CAT#: AP23961PU-N

SH3KBP1 (2-14) goat polyclonal antibody, Aff - Purified

Product Images

Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 2.5 µg/ml.
• Reactivities: Bovine, Canine, Human, Monkey, Mouse, Rabbit, Rat
• Host: Goat
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from positions 2-14 of human SH3KBP1 (NP_114098.1)
• Specificity: This antibody reacts to C-Cbl-interacting Protein (CIN85) (SH3KBP1).
  It antibody is expected to recognize isoform a (NP_114098.1) only.
• Formulation: Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilizer and 0.02% sodium azide as preservative
  State: Aff - Purified
  State: Liquid purfied Ig fraction
• Concentration: 0.5 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens SH3 domain containing kinase binding protein 1 (SH3KBP1), transcript variant 2
• Database Link:
  Entrez Gene 58194 MouseEntrez Gene 84357 RatEntrez Gene 30011 Human
• Background: Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor.
• Synonyms: CIN85, HSB-1, CD2BP3

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Endocytosis