ITK (596-607) Goat Polyclonal Antibody

CAT#: AP23995PU-N

ITK (596-607) goat polyclonal antibody, Aff - Purified

Product Images

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 3.75 - 7.5 µg/ml.
• Reactivities: Human, Monkey
• Host: Goat
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from positions 596-607 of human ITK (NP_005537.3)
• Specificity: This antibody reacts to Interleukin 2 Tyrosine Kinase (ITK) at aa 596-607.
• Formulation: Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilizer and 0.02% sodium azide as preservative
  State: Aff - Purified
  State: Liquid purfied Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens IL2 inducible T-cell kinase (ITK)
• Database Link:
  Entrez Gene 3702 Human
• Background: Interleukin-2 tyrosine kinase (ITK), a BTK/TEC type tyrosine kinase, is critical for efficient signaling downstream of the T cell receptor. Itk is directly phosphorylated and activated by Lck. Subsequently, Itk activates phospholipase C-gamma1, leading to calcium mobilization and extracellular signal-regulated kinase/mitogen-activated protein kinase activation. Itk contains five domains in addition to the catalytic domain: pleckstrin homology, Tec homology which contains a proline-rich region, Src homology 3, and Src homology 2.
• Synonyms: EMT, LYK

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Chemokine signaling pathway, Leukocyte transendothelial migration, T cell receptor signaling pathway