GRIA1 pSer836 Rabbit Polyclonal Antibody

CAT#: AP26044PU-S

GRIA1 pSer836 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of extracts from mouse brain and using GluR1 (phospho-Ser836) Antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1:500 - 1:1000.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide sequence around phosphorylation site of serine 836 derived from Human GluR1
• Specificity: This antibody detects endogenous level of GluR1 only when phosphorylated at serine 836.
• Formulation: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Affinity-chromatography using epitope-specific peptide
• Storage: Store (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens glutamate ionotropic receptor AMPA type subunit 1 (GRIA1), transcript variant 1
• Database Link:
  Entrez Gene 14799 MouseEntrez Gene 50592 RatEntrez Gene 2890 Human
• Background: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Synonyms: GluR-1, GRIA1, GLUH1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA1
• Note: Molecular weight: 110 kDa

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Glutamate Receptors, Transmembrane
• Protein Pathways: Amyotrophic lateral sclerosis (ALS), Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction