Caspase 8 (CASP8) (217-221) Rabbit Polyclonal Antibody

CAT#: AP26061PU-N

Caspase 8 (CASP8) (217-221) rabbit polyclonal antibody, Aff - Purified


USD 300.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Applications WB
Recommended Dilution Western blot: 1:1000.
Reactivities Human
Host Rabbit
Clonality Polyclonal
Immunogen Peptide sequence around aa.217~221 derived from Caspase 8
Specificity This antibody detects endogenous level of total Caspase 8 protein.
Formulation Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
State: Aff - Purified
State: Liquid Ig fraction
Concentration lot specific
Purification Affinity-chromatography using epitope-specific peptide
Storage Store (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens caspase 8 (CASP8), transcript variant F
Background Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
Synonyms CASP-8, CASP8, MCH5, CAP4
Note Molecular weight: 57/45 kDa
Reference Data
Protein Families Druggable Genome, Protease
Protein Pathways Alzheimer's disease, Apoptosis, Huntington's disease, NOD-like receptor signaling pathway, p53 signaling pathway, Pathways in cancer, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Viral myocarditis

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.