Caspase 9 (CASP9) (301-305) Rabbit Polyclonal Antibody

CAT#: AP26062PU-S

Caspase 9 (CASP9) (301-305) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of extracts from 293 and Hela cells using Caspase 9 Antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1:1000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide sequence around aa.301~305 derived from Caspase 9
• Specificity: This antibody detects endogenous level of total Caspase 9 protein.
• Formulation: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Affinity-chromatography using epitope-specific peptide
• Storage: Store (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens caspase 9 (CASP9), transcript variant alpha
• Database Link:
  Entrez Gene 842 Human
• Background: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
• Synonyms: CASP-9, CASP9, MCH6, ICE-LAP6, APAF-3, APAF3
• Note: Molecular weight: 47/37/35 kDa

Reference Data

• Protein Families: Druggable Genome, Protease, Stem cell - Pluripotency
• Protein Pathways: Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Endometrial cancer, Huntington's disease, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Parkinson's disease, Pathways in cancer, Prostate cancer, Small cell lung cancer, VEGF signaling pathway, Viral myocarditis