Lin28 (LIN28A) (1-5) Rabbit Polyclonal Antibody

CAT#: AP26066PU-S

Lin28 (LIN28A) (1-5) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of extracts from HepG2 cells using Lin28 Antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1:1000.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide sequence around aa. 1~5 derived from Human Lin28
• Specificity: This antibody detects endogenous levels of total Lin28 protein.
• Formulation: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific peptide
• Gene Name: Homo sapiens lin-28 homolog A (LIN28A)
• Database Link:
  Entrez Gene 83557 MouseEntrez Gene 500562 RatEntrez Gene 79727 Human
• Background: Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells.
• Synonyms: LIN-28, LIN28A, CSDD1, ZCCHC1
• Note: Molecular weight: 26 kDa

Reference Data

• Protein Families: Transcription Factors