MMP8 Rabbit Polyclonal Antibody

CAT#: AP26349PU-N

MMP8 rabbit polyclonal antibody, Aff - Purified

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot (1-4 µg/ml).
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide surrounding amino acid 448 of rat MMP-8
• Specificity: This antibody recognizes latent (85 kDa) and active forms (25-65 kDa) of MMP8.
• Formulation: Phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: 0.5 mg/ml
• Purification: Affinity chromatography
• Gene Name: Homo sapiens matrix metallopeptidase 8 (MMP8), transcript variant 1
• Database Link:
  Entrez Gene 17394 MouseEntrez Gene 63849 RatEntrez Gene 4317 Human
• Background: The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. Unlike other members of the MMP family, MMP-8 is expressed exclusively in inflammatory conditions. MMP-8 is also the predominant collagenase expressed in ulcers and healing wounds.
• Synonyms: Neutrophil collagenase, Matrix metalloproteinase-8, PMNL collagenase, MMP8, CLG1, PMNL-CL

Reference Data

• Protein Families: Druggable Genome, Protease