Tau (MAPT) Rabbit Polyclonal Antibody

CAT#: AP26351PU-N

Tau (MAPT) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of TAU in rat kidney tissue lysate (Lane 1), 3T3 cell lysate (Lane 2), and Jurkat cell lysate (Lane 3 & 4).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot (0.5-4 µg/ml).
• Reactivities: Bovine, Chicken, Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide surrounding amino acid 395 of rat Tau
• Specificity: This antibody recognizes mainly the truncated Tau (~30 kDa) in samples from human, mouse and rat origins. Other isoforms of Tau at 35 kDa, 60 kDa and 80 kDa can also be recognized.
• Formulation: Phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography
• Storage: Upon receipt, store at -20 °C. For long term storage, aliquot and store at -70 °C. Avoid repeated freezing and thawing.
• Stability: Shelf life: One year from despatch.
• Gene Name: Homo sapiens microtubule associated protein tau (MAPT), transcript variant 6
• Database Link:
  Entrez Gene 17762 MouseEntrez Gene 29477 RatEntrez Gene 4137 Human
• Background: Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyperphosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer’s disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK3. This presents the possibility that miscues in GSK3 signaling contribute to the onset of Alzheimer’s disease.
• Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, PHF-tau, Neurofibrillary tangle protein, Paired helical filament-tau

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Alzheimer's disease, MAPK signaling pathway