STAT4 Rabbit Polyclonal Antibody

CAT#: AP26361PU-N

STAT4 rabbit polyclonal antibody, Aff - Purified

Product Images

Western Blot analysis of STAT4 expression in Rat kidney tissue lysate.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 0.5-4 µg/ml.
• Reactivities: Human, Mouse, Porcine, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide surrounding amino acid 732 of Rat Stat4
• Specificity: The antibody recognizes ~97 kDa Stat4 in samples from Human, Mouse, and Rat origins.
  A ~60 kDa band can also be detected, presumably to be the cleavage fragment of Stat4.
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified IgG fraction
  Stabilizer: 0.5% BSA, 30% Glycerol
  Preservative: 0.01% Thimerosal
• Concentration: lot specific
• Purification: Affinity Chromatography
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: One year from despatch.
• Gene Name: Homo sapiens signal transducer and activator of transcription 4 (STAT4), transcript variant 1
• Database Link:
  Entrez Gene 20849 MouseEntrez Gene 367264 RatEntrez Gene 6775 Human
• Background: Membrane receptor signaling by various ligands induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 is activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.
• Synonyms: OTTHUMP00000163553; SLEB11

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Jak-STAT signaling pathway