Serpinb9 Rabbit Polyclonal Antibody

CAT#: AP26375PU-N

Serpinb9 rabbit polyclonal antibody, Purified

Specifications

Product Data

• Applications: FC, WB
• Recommended Dilution: Flow Cytometry: The typical starting working dilution is 1/50.
  Western blot: The typical starting working dilution is 1/50.
• Reactivities: Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: Recombinant GST-Spi-6
• Specificity: The antibody recognizes Mouse Spi-6, also known as Serpin B9, a cytoplasmic serine protease inhibitor of ~42 kDa.
  It shows no cross-reactivity with Mouse proteins related to Spi-6.
• Formulation: PBS
  State: Purified
  State: Liquid 0.2 µm filtered Ig fraction
  Stabilizer: 0.1% BSA
  Preservative: 0.02% Sodium Azide
• Concentration: 0.1 mg/ml
• Purification: Protein A Chromatography
• Database Link:
  Entrez Gene 20723 Mouse
• Background: Spi-6 is expressed in dendritic cells, lymphocytes and specific cell types at immune-privileged sites. It inactivates granzyme B, a natural occurring inducer of programmed cell death. As such, Spi-6 functions as anti-apoptotic protein. In cytotxic T cells (CTL), Spi-6 is required to protect clonal bursts (expansion) from granzyme B induced cell death. However, it is not required for the development of memory cells. Expression of SPI-6 is of crucial importance in the escape of several tumors from a CTL response and is, therefore, a parameter that influences the feasibility of CTL-mediated immunotherapy of cancer.
• Synonyms: Cytoplasmic antiproteinase 3, serpin B9, PI-9