TJP2 (411-467) Guinea Pig Polyclonal Antibody

CAT#: AP26409PU-N

TJP2 (411-467) guinea pig polyclonal antibody, Purified


USD 425.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Applications IF, IHC, WB
Recommended Dilution Immunohistochemistry on Frozen Sections.
Immunofluorescence. 
Western blot. 
The typical starting working dilution is 1/50.
Reactivities Human, Mouse
Host Guinea Pig
Isotype Ig
Clonality Polyclonal
Immunogen Amino acids 411-467 of Human ZO-2
Specificity This antibody recognizes human zona occludens 2 (ZO-2).
Formulation PBS
State: Purified
State: Liquid 0.2 µm filtered Ig fraction
Stabilizer: 0.1% BSA
Preservative: 0.02% Sodium Azide
Concentration 0.1 mg/ml
Purification Protein A Chromatography
Background

Zona occludens 2 (ZO-2) is an ~160 kDa tight junction protein belonging to the membrane-associated guanlyate kinase (MAGUK) family. Members of this family are involved in epithelial and endothelial intercellular junctions. They each contain at least one PSD95/Dlg/ZO-1 (PDZ) domain, a Src homology 3 (SH3) domain, and an enzymatically inactive guanylate kinase domain. PDZ domains are 90-amino acid protein-protein binding domains that recognize at least a 3-residue peptide motif in the COOH termini of their binding partners. PDZ domain-containing proteins, like ZO-2, typically act as scaffolding proteins that organize membrane receptors and cytosolic proteins into multimeric signaling complexes often at the sites of cell-cell contact. The effectiveness and stability of the epithelial barrier depends on a complex of proteins composing different intercellular junctions, which include tight junctions, adherens junctions, and desmosomes.
ZO-2 can interact with zona occludens 1 (ZO-1). Furthermore, the PDZ2 domain of ZO-2 was shown to interact with connexin-43, the predominant connexin in epithelial and most other tissues which is involved in cell growth control and embryonic development.

Synonyms Tight junction protein 2, Tight junction protein ZO-2, ZO2, X104
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.