Ephrin A5 (EFNA5) (189-200) Goat Polyclonal Antibody

CAT#: AP31011PU-N

Ephrin A5 (EFNA5) (189-200) goat polyclonal antibody, Aff - Purified

Product Images

Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 3.75 - 7.5 µg/ml.
• Reactivities: Bat, Bovine, Canine, Chicken, Equine, Human, Monkey, Mouse, Rabbit, Rat, Xenopus
• Host: Goat
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from positions 189-200 of human EFNA5 (NP_001953.1)
• Specificity: This antibody reacts to Ephrin-a5 (EFNA5) at aa 189-200.
• Formulation: Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilizer and 0.02% sodium azide as preservative
  State: Aff - Purified
  State: Liquid purfied Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens ephrin A5 (EFNA5)
• Database Link:
  Entrez Gene 13640 MouseEntrez Gene 116683 RatEntrez Gene 1946 Human
• Background: Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
• Synonyms: EFNA5, LERK-7, EPLG7, LERK7, AL-1, EPL7

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Axon guidance