GFAP Rabbit Polyclonal Antibody

CAT#: AP31021PU-N

GFAP rabbit polyclonal antibody, Purified

Product Images

Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 1/50.
• Reactivities: Bovine, Chicken, Guinea Pig, Hamster, Human, Monkey, Mouse, Rat, Sheep
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: GFAP isolated from Cow spinal cord
• Specificity: This antibody recognizes Glial Fibrillary Acidic Protein (GFAP).
• Formulation: 10mM PBS, pH 7.4
  State: Purified
  State: Liquid purfied IgG fraction
  Stabilizer: 0.2% BSA
  Preservative: 0.09% Sodium Azide
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens glial fibrillary acidic protein (GFAP), transcript variant 2
• Database Link:
  Entrez Gene 14580 MouseEntrez Gene 24387 RatEntrez Gene 712941 MonkeyEntrez Gene 2670 Human
• Background: Glial fibrillary acidic protein (GFAP) is an intermediate-filament (IF) protein that is highly specific for cells of astroglial lineage, although its tissue-specific role is speculative. GFAP has been located in rat kidney glomeruli and peritubular fibroblasts, leydig cells of testis, skin keratinocytes, osteocytes of bones, chondrocytes of epiglottis, bronchus, and stellate-shaped cells of the pancreas and liver. Its expression is essential for normal white matter architecture and blood-brain barrier integrity, and its absence leads to late-onset CNS dysmyelination. GFAP has also been shown to play a role in mitosis by adjusting the filament network present in the cell. During mitosis, there is an increase in the amount of phosphorylated GFAP, and a movement of this modified protein to the cleavage furrow.
• Synonyms: Glial Fibrillary Acidic Protein

Reference Data

• Protein Families: ES Cell Differentiation/IPS