TIE1 (C-term) Rabbit Polyclonal Antibody

CAT#: AP31041PU-N

TIE1 (C-term) rabbit polyclonal antibody, Purified

Product Images

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 1/50.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to C-terminal of human Tie-1
• Specificity: This antibody reacts to the C-term of Protein Tyrosine Kinase Receptor TIE1.
• Formulation: 10 mM PBS, pH 7.4 containing BSA as stabilizer and 0,09% sodium azide as preservative
  State: Purified
  State: Liquid purfied Ig fraction
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens tyrosine kinase with immunoglobulin like and EGF like domains 1 (TIE1), transcript variant 1
• Database Link:
  Entrez Gene 7075 Human
• Background: TIE1 is a receptor that is implicated in vessel maturation and angiogenesis. TIE1 contains immunoglobulin-like loops and epidermal growth factor (EGF) homology domains.
  TIE1/TIE (tyrosine kinase with Ig and EGF homology domains 1) and TIE2/Tek define a new class of the receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin like domains flanking three epidermal growth factor (EFG) like domains followed by three fibronectin type III like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. Human TIE1 cDNA encodes a 1138 amino acid residue precursor protein with a putative signal peptide, an extracellular domain, and a cytoplasmic domain. TIE1 and TIE2, expressed primarily on endothelial and hematopoietic progenitor cells, play important roles in angiogenesis, vasculogenesis, and hematopoiesis. In developing vascular endothelial cells, TIE1 and TIE2 are specifically expressed. Two ligands that bind TIE have been identified, angiopoietin 1 and angiopoietin 2. Based on gene targeting studies, the in vivo functions of TIE1 are related to endothelial cell differentiation.
• Synonyms: TIE, Tie-1

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transmembrane