MCL1 (121-139) Rabbit Polyclonal Antibody

CAT#: AP31050PU-N

MCL1 (121-139) rabbit polyclonal antibody, Purified

Product Images

Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 1/25 - 1/100.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide corresponding to aa 121-139 of human Mcl-1
• Specificity: This antibody reacts to Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1).
• Formulation: 10 mM PBS, pH 7.4 containing 1% BSA as stabilizer and 0,09% sodium azide as preservative
  State: Purified
  State: Liquid purfied Ig fraction
• Purification: Immunoaffinity Chromatography
• Storage: Store the antibody undiluted at 2-8°C.
  DO NOT FREEZE!
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens myeloid cell leukemia 1 (MCL1), transcript variant 3
• Database Link:
  Entrez Gene 4170 Human
• Background: Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival. While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak. Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis (5) and for the development and maintenance of B and T lymphocytes in animals. Mcl-1 exists as at least two distinct isoforms designated Mcl-1L and Mcl-1S. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death.
• Synonyms: BCL2L3, Bcl-2-like protein 3, mcl1/EAT, EAT, r004

Reference Data

• Protein Families: Druggable Genome, Transmembrane