RNF86 (TRIM2) (758-771) Goat Polyclonal Antibody

CAT#: AP31074PU-N

RNF86 (TRIM2) (758-771) goat polyclonal antibody, Aff - Purified

Product Images

TRIM2 antibody staining of Rat Brain lysate at 0.5 mg/ml (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

• 

  Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/16000.
  Immunohistochemistry on Paraffin Sections: 6.25 µg/ml.
  Western Blot: 0.5 - 2 µg/ml.
• Reactivities: Bat, Bovine, Canine, Chicken, Equine, Hamster, Human, Monkey, Mouse, Rabbit, Rat, Xenopus, Zebrafish
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from the C-terminus of human TRIM2 / RNF86 (NP_056086.2; NP_001123539.1)
• Specificity: Recognizes Tripartite Motif Protein TRIM2 at aa 758-771.
  It is expected to recognise both reported isoforms (NP_056086.2; NP_001123539.1).
  Cross-reactivity with TRIM3 has been demonstrated.
• Formulation: Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilizer and 0.02% Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified IgG fraction
• Concentration: 0.5 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens tripartite motif containing 2 (TRIM2), transcript variant 2
• Database Link:
  Entrez Gene 80890 MouseEntrez Gene 361970 RatEntrez Gene 23321 Human
• Background: KIAA0517 / TRIM2 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants.
• Synonyms: KIAA0517, RING finger protein 86
• Note: Calculated Molecular Weight: 81.5 kDa (Human NP_001123539.1), 84.4 KDa (Human NP_056086.2) and 83.3 kDa (Rat NP_001102022.1).