GRIA1 (264-277) Goat Polyclonal Antibody

CAT#: AP31107PU-N

GRIA1 (264-277) goat polyclonal antibody, Aff - Purified

Product Images

GLUR1 antibody staining of Human Cerebellum lysate at 0.1 ug/ml (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Specifications

Product Data

• Applications: ELISA, WB
• Recommended Dilution: Peptide ELISA: Detection Limit: 1/16000.
  Western Blot: 0.1-0.3 µg/ml. Approx 100kDa band observed in Human, Mouse and Rat Brain (Cerebellum) lysates.
• Reactivities: Human, Mouse, Rat
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_000818.2; NP_001107655.1.
• Specificity: This antibody is expected to recognize both reported isoforms (NP_000818.2 and NP_001107655.1).
• Formulation: Tris saline, pH~7.3 with 0.02% Sodium Azide and 0.5% BSA
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens glutamate ionotropic receptor AMPA type subunit 1 (GRIA1), transcript variant 1
• Database Link:
  Entrez Gene 14799 MouseEntrez Gene 50592 RatEntrez Gene 2890 Human
• Background: Glutamate dehydrogenase has a central role in nitrogen metabolism in plants and animals. Glutamate dehydrogenase is found in all organisms and catalyzes the oxidative deamination of 1-glutamate to 2-oxoglutarate. Glutamate, the main substrate of Glutamate dehydrogenase, is present in brain in concentrations higher than in other organs. In nervous tissue, Glutamate dehydrogenase appears to function in both the synthesis and the catabolism of glutamate and perhaps in ammonia detoxification.
• Synonyms: GluR-1, GRIA1, GLUH1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA1
• Note: Calculated Molecular Weight: 102kDa (NP_000818.2).

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Glutamate Receptors, Transmembrane
• Protein Pathways: Amyotrophic lateral sclerosis (ALS), Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction