Parathyroid Hormone Receptor 1 (PTH1R) Rabbit Polyclonal Antibody

CAT#: AP31230PU-N

Parathyroid Hormone Receptor 1 (PTH1R) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of extracts from Jurkat cells, using PTHR1 Antibody. The lane on the right is treated with the synthesized peptide.

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  Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Immunofluorescence analysis of MCF7 cells, using PTHR1 Antibody. The picture on the right is treated with the synthesized peptide.

Specifications

Product Data

• Applications: ELISA, IF, IHC, WB
• Recommended Dilution: ELISA: 1/10000.
  Immunofluorescence: 1/100 - 1/500.
  Immunohistochemistry on Paraffin Sections: 1/200.
  Western Blot: 1/500 - 1/1000.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from human PTHR1 (aa145-194).
• Specificity: This antibody reacts to the internal region of PTH1R / PTHR1.
• Formulation: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity chromatography
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens parathyroid hormone 1 receptor (PTH1R), transcript variant 1
• Database Link:
  Entrez Gene 19228 MouseEntrez Gene 56813 RatEntrez Gene 5745 Human
• Background: PTHR1, a Parathyroid Hormone Receptor, mediates PTH-dependent regulation of mineral-ion homeostasis. It also mediates the paracrine action of PTHRP in endochondral bone formation. Mutations in this receptor are responsible for disorders of calcium and bone metabolism such as chondrodysplasia, hypercalcemia, and chronic renal failure. Three promoters, P1, P2, and P3, regulate the expression of PTHR.
• Synonyms: Parathyroid hormone 1 receptor, PTH/PTHrP type I receptor, PTH1R, PTHR, PTHR1

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction