Tyrosine Hydroxylase (TH) (N-term) Rabbit Polyclonal Antibody

CAT#: AP31262PU-N

Tyrosine Hydroxylase (TH) (N-term) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of extracts from NIH-3T3 cells, treated with Forskolin 40nM 30', using Tyrosine Hydroxylase Antibody. The lane on the right is treated with the synthesized peptide.

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  Human Adrenal Medulla: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Immunofluorescence analysis of HuvEc cells, using Tyrosine Hydroxylase Antibody. The picture on the right is treated with the synthesized peptide.

Specifications

Product Data

• Applications: ELISA, IF, IHC, WB
• Recommended Dilution: ELISA: 1/20000.
  Immunofluorescence: 1/100 - 1/500.
  Immunohistochemistry on Paraffin Sections: 1/100.
  Western Blot: 1/500 - 1/1000.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide - KLH conjugated
• Specificity: Tyrosine Hydroxylase (Ab-40) Antibody detects endogenous levels of total Tyrosine Hydroxylase protein.
• Formulation: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: 1,0 mg/ml
• Purification: Immunoaffinity chromatography
• Gene Name: Homo sapiens tyrosine hydroxylase (TH), transcript variant 2
• Database Link:
  Entrez Gene 21823 MouseEntrez Gene 25085 RatEntrez Gene 7054 Human
• Background: Tyrosine hydroxylase in involved in the conversion of phenylalanine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines and as such has a key role in the physiology of adrenergic neurons. TH is encoded by four distinct mRNAs produced by alternative splicing of a single primary transcript. Expression of the mRNAs varies in different parts of the nervous system. Defects in TH are the cause of autosomal recessive Segawa syndrome.
• Synonyms: Tyrosine 3-hydroxylase, TYH

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, Parkinson's disease, Tyrosine metabolism