RHOH (C-term) Rabbit Polyclonal Antibody

CAT#: AP31335PU-N

RHOH (C-term) rabbit polyclonal antibody, Purified


USD 440.00

2 Weeks*

Size
    • 50 ul

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Specifications

Product Data
Applications ELISA, IF, IHC, WB
Recommended Dilution ELISA: 1/5000.
Immunofluorescence: 1/100 - 1/500.
Immunohistochemistry on Paraffin Sections: 1/200.
Western Blot: 1/500 - 1/1000.
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide - KLH conjugated
Specificity This antibody detects endogenous levels of total RhoH protein.
Formulation PBS (without Mg2+, Ca2+), pH 7.4 containing 150 mM Sodium Chloride, 0.02% Sodium Azide and 50% Glycerol.
State: Purified
State: Liquid purified IgG fraction.
Concentration lot specific
Purification Immunoaffinity Chromatography.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens ras homolog family member H (RHOH), transcript variant 6
Background The Rho subfamily of small GTP-binding proteins mediates many fundamental cellular functions. The commonly studied members (Rho, Rac, and CDC42) regulate actin reorganization and affect diverse cellular responses, including adhesion, cytokinesis, and motility. RhoH, also known as TTF (Translocation Three Four), Rho-related GTP-binding protein and ras homolog gene family member H, is unlike most other small G proteins. Most small G proteins are expressed ubiquitously, however, Rho H is expressed only in hemopoietic cells and tissues. Translocations and a high frequency of Rho H mutation have been detected in primary lymphoma cells. Rho H expression has also been observed in activated neutrophils. RhoH is GTPase deficient, remaining in a GTP-bound activated state without cycling. Rho H may be involved in the functional differentiation of T cells and in cytoskeleton organization. The RhoH/TTF (ARHH) gene maps to chromosome 4p13 and encodes a 191 -amino acid polypeptide.
Synonyms ARHH, TTF
Reference Data
Protein Families Transcription Factors
Protein Pathways Leukocyte transendothelial migration

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.