Aurora B (AURKB) Rabbit Polyclonal Antibody

CAT#: AP31338PU-N

Aurora B (AURKB) rabbit polyclonal antibody, Purified


USD 440.00

2 Weeks*

Size
    • 50 ul

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Specifications

Product Data
Applications ELISA, IF, IHC, WB
Recommended Dilution ELISA: 1/1000.
Immunofluorescence: 1/100 - 1/500.
Immunohistochemistry on Paraffin Sections: 1/200.
Western Blot: 1/500 - 1/1000.
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide - KLH conjugated
Specificity This antibody detects endogenous levels of total AurB protein.
Formulation PBS (without Mg2+, Ca2+), pH 7.4 containing 150 mM Sodium Chloride, 0.02% Sodium Azide and 50% Glycerol.
State: Purified
State: Liquid purified IgG fraction.
Concentration 1.0 mg/ml
Purification Immunoaffinity Chromatography.
Gene Name Homo sapiens aurora kinase B (AURKB), transcript variant 1
Background ARK2, an Aurora/IPL1-like protein kinase, functions in bipolar chromosome orientation, kinetochore assembly, spindle checkpoint and microtubule dynamics, and chromosome condensation and cohesion. ARK2 has been shown to be physically associated with inner centromere protein (INCENP) during mitosis, and activated ARK2 has been shown to phosphorylate histone H3. The Ark2 gene has been mapped to 17p13.1, a region that is frequently deleted in tumors, and has been shown to be transcriptionally overexpressed in many tumor cell lines. Overexpression of ARK2 disrupts cleavage furrow formation without affecting nuclear division, often resulting in multinuclearity and polyploidy.
Synonyms Aurora-B, Aurora/IPL1-related kinase 2, STK-1, AURKB, AIK2, AIM1, ARK2, STK12
Reference Data
Protein Families Druggable Genome, Protein Kinase, Stem cell - Pluripotency

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.