Calcineurin A (PPP3CA) (N-term) Rabbit Polyclonal Antibody

CAT#: AP31352PU-N

Calcineurin A (PPP3CA) (N-term) rabbit polyclonal antibody, Purified

Product Images

Western blot of anti-PPP3CA AP31352PU-N in mouse kidney tissue lysate. PPP3CA (arrow) was detected using the purified Pab

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  Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Intestine, Muscularis Propria: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Tonsil, Lymphocytes: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 1/1000.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 21-51 amino acids from the N-terminal region of human Calcineurin (PPP3CA).
• Specificity: This antibody detects PPP3CA / Calcineurin A (N-term).
• Formulation: PBS containing 0.09% Sodium Azide as preservative.
  State: Purified
  State: Liquid purified Ig fraction.
• Purification: Ammonium Sulfate Precipitation.
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens protein phosphatase 3 catalytic subunit alpha (PPP3CA), transcript variant 1
• Database Link:
  Entrez Gene 19055 MouseEntrez Gene 5530 Human
• Background: Calcineurin A alpha (PPP3CA), a PP2B type serine/threonine phosphatase, is a catalytic subunit of calcineurin which acts as a calcium-dependent and calmodulin-stimulated modifier of phosphorylation status. PPP3CA has been shown to function in calcium signaling and is believed to function in the calmodulin activation of calcineurin, motor neuron disease and neuronal reorganization after ischemic injury. Based on studies in knockout mice, PPP3CA has been implicated in learning and memmory via hippocampal cytoskeletal changes.
• Synonyms: CALNA, CNA, PP2B catalytic subunit, protein phosphatase 2B catalytic subunit alpha

Reference Data

• Protein Families: Druggable Genome, Phosphatase
• Protein Pathways: Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Axon guidance, B cell receptor signaling pathway, Calcium signaling pathway, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, T cell receptor signaling pathway, VEGF signaling pathway, Wnt signaling pathway