Endostatin (COL18A1) (801-850) Rabbit Polyclonal Antibody

CAT#: AP31363PU-N

Endostatin (COL18A1) (801-850) rabbit polyclonal antibody, Aff - Purified

Product Images

Human Breast, Collagen: Formalin-Fixed, Paraffin-Embedded (FFPE).

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  Immunofluorescence analysis of A549 cells, using Collagen XVIII alpha1 Antibody. The picture on the right is treated with the synthesized peptide.

Specifications

Product Data

• Applications: ELISA, IF, IHC
• Recommended Dilution: ELISA: 1/5000.
  Immunofluorescence: 1/100 - 1/500.
  Immunohistochemistry on Paraffin Sections: 1/100.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from Human Collagen XVIII alpha1 (aa801-850)
• Specificity: This antibody detects endogenous levels of total Collagen XVIII alpha1 protein.
• Formulation: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM Sodium Chloride, 0.02% Sodium Azide and 50% Glycerol
  State: Aff - Purified
  State: Liquid purified IgG fraction
• Concentration: 1.0 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens collagen type XVIII alpha 1 (COL18A1), transcript variant 1
• Database Link:
  Entrez Gene 12822 MouseEntrez Gene 80781 Human
• Background: COL18A1 encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure.
• Synonyms: COL18A1, Endostatin, KNO1