EDD (UBR5) (69-79) Goat Polyclonal Antibody

CAT#: AP31432PU-N

EDD (UBR5) (69-79) goat polyclonal antibody, Aff - Purified

Product Images

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: ELISA: 1/4000.
  Immunohistochemistry on Paraffin Sections: 3.75 µg/ml.
• Reactivities: Bovine, Bat, Chicken, Equine, Hamster, Human, Insect, Monkey, Mouse, Rabbit, Rat, Xenopus, Zebrafish
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from C-terminus of human UBR5
• Specificity: This antibody reacts to UBR5 at aa 69-79.
• Formulation: Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilizer and 0.02% sodium azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 0.5 mg/ml
• Purification: Immunoaffinity chromatography
• Gene Name: Homo sapiens ubiquitin protein ligase E3 component n-recognin 5 (UBR5), transcript variant 1
• Database Link:
  Entrez Gene 70790 MouseEntrez Gene 117060 RatEntrez Gene 51366 Human
• Background: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function.
• Synonyms: EDD, EDD1, KIAA0896

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Ubiquitin mediated proteolysis